ASINEX-REAG BAS 16579166

Name	N-acetyl-L-proline
Synonyms	Ac-Pro-OH NSC 280718 N-Ac-Pro-OH ACETYL-L-PROLINE Acetyl-L-Proline L-N-Acetylproline N-acetyl-L-proline (S)-N-Acetylproline ASINEX-REAG BAS 16579166 (2R)-1-acetylpyrrolidine-2-carboxylate (2S)-1-acetyl-2-pyrrolidinecarboxylate (2S)-1-acetylpyrrolidine-2-carboxylate N-AN-Acetyl-L-prolineN-Acetyl-L-prolinecetyl-L-proline
CAS	68-95-1
EINECS	200-698-9
InChI	InChI=1/C7H11NO3/c1-5(9)8-4-2-3-6(8)7(10)11/h6H,2-4H2,1H3,(H,10,11)/p-1/t6-/m0/s1
InChIKey	GNMSLDIYJOSUSW-LURJTMIESA-N

Molecular Formula	C7H11NO3
Molar Mass	157.17
Density	1.274±0.06 g/cm3(Predicted)
Melting Point	115-117 °C
Boling Point	366.2±35.0 °C(Predicted)
Specific Rotation(α)	-86 º (c=1 EtOH)
Flash Point	175.3°C
Solubility	Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
Vapor Presure	2.31E-06mmHg at 25°C
Appearance	Solid
Color	White to off-white
BRN	83200
pKa	3.69±0.20(Predicted)
Storage Condition	2-8°C
MDL	MFCD00020837

Hazard Symbols	Xi - Irritant
Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29339900
Hazard Class	IRRITANT

NIST chemical information	information provided by: webbook.nist.gov (external link)
Application	N-acetyl-L-proline is an acetylated product of L-proline. It can be prepared by one-step reaction of L-proline with acetic anhydride. N-acetyl amino acids are important fine organic chemical intermediates, which are widely used in medicine, pesticide, chemical industry and other fields.
preparation	35gL-proline and water were mixed and dissolved, stirred evenly, and saturated sodium carbonate solution was gradually added dropwise to adjust the pH to 7.5; wait for the temperature to drop to 10 °c, add 32ml of anhydride Dropwise, and maintain pH = 7.5 during the dropwise addition; After the dropwise addition, raise the temperature to 25 °c, and react for about 6 hours, no raw material was controlled in the spot plate, and the reaction was finished. Adjust the pH of the reaction solution to 1, and then extract 4 * 30mL with ethyl acetate, 45.11g (purity 98.6%, yield 93.1%) of N-acetyl-L-proline was obtained as an oil.

Last Update：2024-04-09 21:00:56

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QQ: 2853786052

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Product Name: N-Acetyl-L-Proline Visit Supplier Webpage Request for quotation
CAS: 68-95-1
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QQ: 3008007409

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ASINEX-REAG BAS 16579166

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